क्लोरैम्बुसिल हिंदी उपयोग और उदाहरण

"" प्राथमिक तौर पर कीमोथेरपी संबंधी उपचार में संयोजन कीमोथेरपी के साथ क्लोरैम्बुसिल या साईक्लोफॉस्फोमाईड और साथ ही साथ एक कॉर्टिकॉस्टेरॉयड जैसे कि प्रेडनिसोन या प्रेडनिसोलोन का प्रयोग किया जाता है।

प्राथमिक तौर पर कीमोथेरपी संबंधी उपचार में संयोजन कीमोथेरपी के साथ क्लोरैम्बुसिल या साईक्लोफॉस्फोमाईड और साथ ही साथ एक कॉर्टिकॉस्टेरॉयड जैसे कि प्रेडनिसोन या प्रेडनिसोलोन का प्रयोग किया जाता है।

क्लोरैम्बुसिल इसके अंग्रेजी अर्थ का उदाहरण

Chlorambucil's current use is mainly in chronic lymphocytic leukemia, as it is well tolerated by most patients, though chlorambucil has been largely replaced by fludarabine as first-line treatment in younger patients.

Bone marrow suppression (anemia, neutropenia, thrombocytopenia) is the most commonly occurring side effect of chlorambucil.

Like many alkylating agents, chlorambucil has been associated with the development of other forms of cancer.

The precise mechanisms by which chlorambucil acts to kill tumor cells are not yet completely understood.

This is important since chlorambucil, as an electrophile, is made less reactive by conjugation with glutathione, thereby making the drug less toxic to the cell.

Shown above, chlorambucil reacts with glutathione as catalyzed by hGSTA 1-1 leading to the formation of the monoglutathionyl derivative of chlorambucil.

In the 1950s, aromatic mustards like chlorambucil were introduced as less toxic alkylating agents than the aliphatic nitrogen mustards, proving to be less electrophilic and react with DNA more slowly.

Chemotherapies with high risk of infertility include procarbazine and other alkylating drugs such as cyclophosphamide, ifosfamide, busulfan, melphalan, chlorambucil and chlormethine.

Oral alkylating agents such as cyclophosphamide or chlorambucil have been administered for a median duration of 12 months with high rates of disease control (CR up to 75%) but appear not to be active in t(11;18) disease.

A pivotal study of rituximab plus chlorambucil compared with chlorambucil alone (IELSG-19 study, n 227) demonstrated a significantly higher CR rate (78% vs.

024) over chlorambucil alone.